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0:19
phys.org
Justin Jackson
Previously unknown mechanism in precision RNA cleaving by Dicer enzyme revealed
Stem recognition by dsRBD and RIIID. The C-terminal dsRBD of DICER shows a large conformational change to accommodate dsRNA in the catalytic valley. Near the cleavage sites, this major groove of the RNA helix is expanded and sandwiched between dsRBD and RIIIDa. The mismatch of the GYM motif is recognized by R1855 of dsRBD. Credit: Nature (2023 ...
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