The scFv-Fc format allows for rapid characterization of candidate scFvs isolated from phage display libraries before conversion into a full-length IgG. This format offers several advantages …

A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (V H) and light chains (V L) of …

These novel bovine scFvs-Fc Abs may be useful as therapeutic candidates for the prevention and treatment of S. aureus-induced bovine mastitis. Keywords: Bovine mastitis; Fc; Phagocytosis; …

In this study, we report a newly designed anti-METH scFv-Fc biotherapeutic (7F9-Fc) packaged into an AAV8 viral vector. We report a dose-dependent relationship between the AAV8 viral …

Dec 15, 2011 · Cell surface chondroitin sulfate proteoglycan 4 (CSPG4) is an attractive target for antibody-based cancer immunotherapy because of its role in tumor cell biology, its high …

Jan 1, 2014 · The scFv-Fc format, with its straightforward cloning and expression procedure, allows for rapid characterization of candidate scFvs isolated from phage display libraries with …

Conversion of scFv into scFv-Fc fusion. TGEX-SCblue vector contains a double SfiI restriction site found in all pADL phagemids. A lacZ fragment in the cloning site allows for quick identification …

Here, we advance our approach by generating a novel anti-METH single-chain variable fragment (scFv)-Fc fusion construct (termed 7F9-Fc) packaged into AAV serotype 8 vector (called AAV …

Aug 1, 2017 · This report describes the generation of a potent, fully human antibody fragment in scFv-Fc format efficiently targeting FGFR1. Antibody phage display was used to select high …

A popular approach has been to fuse scFv to the hinge and Fc regions of immunoglobulins (scFv-Fc) or to just the third constant domain of IgG (scFv-C H3), with or without a hinge region.