Complex roles of cAMP-PKA-CREB signaling in cancer
Nov 24, 2020 · Aberrant cAMP-PKA signaling is involved in various types of human tumors. Especially, cAMP signaling may have both tumor-suppressive and tumor-promoting roles …
CREB - Wikipedia
CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca 2+ /calmodulin-dependent protein kinases on the Serine 133 residue. [7] When activated, CREB …
cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach
There may be an impact on gene transcription from protein kinase A (PKA) as well as its downstream effectors, such as cAMP response element-binding protein (CREB). The position …
Complex roles of cAMP–PKA–CREB signaling in cancer
Nov 24, 2020 · This review highlights the important roles of cAMP–PKA–CREB signaling in tumorigenesis. The potential strategies to target this pathway for cancer therapy are also …
Transcriptional regulation by the phosphorylation-dependent factor CREB …
Aug 1, 2001 · Phosphorylation of CREB family members promotes target gene expression through the recruitment of the coactivator CREB-binding protein (CBP) and its paralogue p300.
The LysoPS/GPR174 axis drives metastatic progression in …
5 days ago · Nuclei contain cyclic AMP response element-binding protein (CREB), a transcription factor. CREB, an important downstream factor of PKA, can be phosphorylated by PKA [18, …
The LysoPS/GPR174 axis drives metastatic progression in
5 days ago · Conclusions: Our study demonstrates that the LysoPS/GPR174 axis, through the cAMP-PKA-CREB pathway, plays a crucial role in promoting the invasion and metastasis of …
cAMP-PKA Pathway: Key Regulator of Cellular Functions
Jan 11, 2025 · Explore how the cAMP-PKA pathway intricately regulates cellular functions, impacting metabolism, gene transcription, and pathway interactions. The cAMP-PKA pathway …
Reducing PKCδ inhibits tumor growth through growth hormone …
Apr 3, 2025 · PMA activated the PKA/CREB/ERK signaling pathway in GH3 cells. PMA, a PKC activator, was applied to investigate the biological function of Protein kinases C (PKCs) and its …
CREB and the CRTC co-activators: sensors for hormonal and
Feb 23, 2011 · Cyclic AMP-responsive element-binding protein (CREB) mediates induction of cAMP-responsive genes following its phosphorylation at Ser133 by protein kinase A (PKA).