Mar 30, 2025 · CDKN1A (Cyclin Dependent Kinase Inhibitor 1A) is a Protein Coding gene. Diseases associated with CDKN1A include Bladder Cancer and Hyperparathyroidism. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Defective binding of RB1 mutants to E2F1, (E2F2, E2F3).

Mar 30, 2025 · PAK4 (P21 (RAC1) Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include Prostate Cancer and Adenomyosis. Among its related pathways are Integrin Pathway and Nervous system development.

Mar 30, 2025 · Complete information for CDKN2A gene (Protein Coding), Cyclin Dependent Kinase Inhibitor 2A, including: function, proteins, disorders, pathways, orthologs, and expression.

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Mar 30, 2025 · This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac.

Mar 30, 2025 · This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1.

Mar 30, 2025 · Complete information for RASA2 gene (Protein Coding), RAS P21 Protein Activator 2, including: function, proteins, disorders, pathways, orthologs, and expression.

Mar 30, 2025 · HRAS (HRas Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with HRAS include Costello Syndrome and Schimmelpenning-Feuerstein-Mims Syndrome. Among its related pathways are Prolactin Signaling and Downstream signaling of activated FGFR2.

Mar 30, 2025 · TP53COR1 (Tumor Protein P53 Pathway Corepressor 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TP53COR1 include Atherosclerosis and B-Cell Lymphoma.

Mar 30, 2025 · This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region.