Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.

Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.

Oct 1, 2022 · Recently, IL-6 secretion was shown to form the backbone of hypercytokinemia seen in the Coronavirus disease 2019 (COVID-19)-associated hyperinflammation and multiorgan failure. There are two classes of approved IL-6 inhibitors: anti-IL-6 receptor monoclonal antibodies (e.g., tocilizumab) and anti-IL-6 monoclonal antibodies (i.e., siltuximab).

Mar 30, 2025 · IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

IL-6: a nexus for immune responses and disease Keywords: cytokine storm of COVID-19, IL-6 amplifier, local initiation model, NF-κB, STAT3

Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.

In this review, we will discuss how the IL-6 signaling pathway influences the adaptive immune response, promotes autoimmunity and how blocking different aspects of this pathway is advantageous in the treatment of disease. IL-6 promotes Th17 and Tfh cell development while suppressing Treg induction

A humanized antibody against the IL-6 receptor, tocilizumab, has exhibited outstanding therapeutic efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, Castleman’s disease, and other autoimmune inflammatory diseases, leading …

Jul 9, 2024 · INTRODUCTION Interleukin 6 (IL-6) is a potent proinflammatory mediator that is important in immune defense and in immune-mediated disease.

Interleukin-6 (IL-6) is a pleiotropic cytokine originally discovered by the Japanese immunologist Kishimoto's group and encoded by the IL-6 gene in humans (Ferguson-Smith et al., 1988), whose main role is to be as a pro-inflammatory cytokine.