HDAC7-mediated PPP engagement via 6-phosphogluconate dehydrogenase (6PGD) generates NADPH for antimicrobial ROS production, as well as D-ribulose-5-phosphate (RL5P) that both …

HDAC7 promotes the PPP, antimicrobial ROS, and bacterial killing in macrophages, whilst also suppressing inflammatory responses in this setting [11]. This function relies, at least in part, on …

Histone deacetylase 7 (HDAC7) is a lysine deacetylase and scaffolding protein that regulates numerous cellular and developmental processes via its multifaceted roles in signal …

Oct 7, 2024 · In macrophages, HDAC7 is a cytoplasmic protein with both pro- and anti-inflammatory functions, with the latter activity involving activation of the pentose phosphate …

Given that HDAC7 constrains Escherichia coli-inducible IL-1β through the PPP (Fig. 6B), this suggests an additional ROS-independent mechanism of regulatory control by this pathway.

Jan 24, 2023 · HDAC7-mediated PPP engagement via 6-phosphogluconate dehydrogenase (6PGD) generates NADPH for antimicrobial ROS production, as well as D-ribulose-5 …

This review focuses on the cell biology of HDAC7, including the regulation of its cellular localisation and molecular mechanisms of action, as well as its associative and causal links …

Nov 6, 2024 · HDAC7 promotes the PPP, antimicrobial ROS, and bacterial killing in macrophages, whilst also suppressing inflammatory responses in this setting [11]. This function relies, at …

HDAC7-mediated PPP engagement via 6-phosphogluconate dehydrogenase (6PGD) generates NADPH for antimicrobial ROS production, as well as D-ribulose-5-phosphate (RL5P) that both …

Parallel to glycolysis, the PPP has a specialized role in innate immune cells in generating reducing power for the respiratory burst, and there is some evidence that classical HDACs …