EIF4E with 7MetGTP 4EBP (red) bound to the alpha helices (cyan) of eIF4E. Eukaryotic translation initiation factor 4E , also known as eIF4E , is a protein that in humans is encoded …

Aug 23, 2023 · In this review, we summarize the biological functions and the research progress of eIF4E, the main influencing factors of eIF4E activity, and the recent progress of drugs …

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA translation has been clearly assessed in the last decades. eIF4E function is essential for …

eIF4E's primary structure (Fig. 1A) is highly conserved in all eukaryotes because of the important role they play in the cell. In the N-terminal end, sequences are variable between different …

Mar 28, 2025 · The antiviral drug ribavirin relocalizes nuclear EIF4E to the cytoplasm and reduces the elevated EIF4E levels found in acute myeloid leukemia patients, suggesting its potential …

eIF4E is a critical node in an RNA regulon impacting cell cycle progression. eIF4E coordinately promotes mRNA export of cell cycle genes. eIF4E moves human epithelial cells along the …

Nov 23, 2018 · Top left: Decreased phosphorylation of eIF4E promotes depressive and anxiety behaviors by relieving translational repression of pro-inflammatory mRNAs containing …

May 25, 2004 · Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes.

eIF4E and translation initiation is an attractive target for anticancer therapeutics because it is a common downstream node on which multiple oncogenic signaling pathways converge.

Nov 6, 2006 · This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical node in an RNA regulon that impacts nearly every stage of cell cycle progression. …