Mar 30, 2025 · CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include Hematologic Cancer and Leukemia, Acute Lymphoblastic . Among its related pathways are Signaling by ALK and Phosphorylation of CD3 and TCR zeta chains .

Mar 30, 2025 · Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T …

Mar 30, 2025 · An important paralog of this gene is CD274. UniProtKB/Swiss-Prot Summary for PDCD1LG2 Gene Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner.

Mar 30, 2025 · CMTM6 (CKLF Like MARVEL Transmembrane Domain Containing 6) is a Protein Coding gene. Among its related pathways is Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of …

Showing 25 of 5,317 results for CD274 Search Time: 0 ms in Aliases & Descriptions Drugs & Compounds Disorders Text-Mined Disorders Domains Expression in Human Tissues Function Genomics Localization Orthologs Paralogs Pathways Phenotypes Proteins Publications Summaries Transcripts Variants in category Protein Coding RNA Gene Functional Element ...

Mar 30, 2025 · CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Combined T Cell And B Cell Immunodeficiency. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

Mar 30, 2025 · CD276 (CD276 Molecule) is a Protein Coding gene. Diseases associated with CD276 include Long Qt Syndrome and Glioma Susceptibility 1. Among its related pathways are T cell modulation in pancreatic cancer and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

Mar 30, 2025 · PSMB9 (Proteasome 20S Subunit Beta 9) is a Protein Coding gene. Diseases associated with PSMB9 include Proteasome-Associated Autoinflammatory Syndrome 6 and Proteasome-Associated Autoinflammatory Syndrome 3 .

Mar 30, 2025 · Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.

Mar 28, 2025 · The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.