Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in response to the binding of membrane -impermeable peptide hormones to the external cell surface. [1]

This page delves into the roles of receptor guanylyl cyclases in signal transduction, emphasizing their conversion of GTP to cGMP and their influence on intracellular signaling.

Jul 30, 2023 · Guanylyl cyclase (also known as guanylate cyclase) is an enzyme that catalyzes the synthesis of cyclic guanosine 3′,5′-monophosphate (cGMP) from guanosine 5' triphosphate (GTP). Guanylyl cyclase exists in both a membrane-bound and soluble form in the cell.

Guanylate cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming)) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate: [1]

Sep 26, 2022 · Guanylate cyclase (GC) is a lyase enzyme that catalyzes the synthesis of cGMP. Guanylate cyclase usually interacts with the G protein cascade, which is activated by low levels of calcium levels. In response to calcium, GC converts Guanosine-5' …

Apr 1, 2024 · Cyclic guanosine monophosphate (cGMP) is synthesized from guanosine triphosphate (GTP) by the enzyme guanylate cyclase (GC). This process is crucial for the generation of cGMP, a second messenger molecule that …

We will describe how to measure soluble guanylyl cyclase (GC1) activity by using a radiolabeled GTP (the substrate), and how to assess NO-cGMP signaling by assaying phosphorylation of the vasodilator-stimulated phosphoprotein (VASP), a downstream effector of the NO-sGC-cGMP signaling pathway.

Stimulation of guanylyl cyclases and the resultant accumulation of cGMP regulates complex signaling cascades through immediate downstream effectors, including cGMP-dependent protein kinases, cGMP-regulated phosphodiesterases, and cyclic nucleotide-gated ion channels.

Dec 20, 2019 · Cyclic guanosine 3′,5′‐monophosphate (cGMP) is an intracellular signalling molecule involved in many sensory and developmental processes. Synthesis of cGMP from GTP is catalysed by guanylate cyclase (GC) in a reaction analogous to …

In this review, we outline each step of the cGMP signaling cascade and discuss its regulation and physiologic effects within the cardiovascular system. In addition, we illustrate how cGMP signaling becomes dysregulated in specific cardiovascular disease states.