Mar 17, 2022 · In this study, we use a chemical proteomics strategy that has identified STAT3, a transcription factor considered to be undruggable, as a direct functional protein target of …

Jan 27, 2022 · STAT3 regulates AML-specific expression of MYC, which in turn controls transcription of the neutral amino acid transporter gene SLC1A5. We show that genetic …

Mar 17, 2022 · Sun et al. show that rapamycin modulates STAT3 function directly and inhibits c-Myc-regulated gene expression. Moreover, rapamycin decreases STAT3 and c-Myc …

Jun 12, 2001 · We show here that disruption of Stat3 signaling by using dominant-negative Stat3β protein in NIH 3T3 fibroblasts suppresses c-Myc expression concomitant with inhibition of v …

Several oncogenic targets of STAT3 have been recently identified such as c-myc, c-Jun, PLK-1, Pim1/2, Bcl-2, VEGF, bFGF, and Cten, and inhibitors of STAT3 have been developed for …

Instead, we suggested that STAT3 is essential for the rapid IL-6– induced or gp130-mediated induction of the c-myc mRNA expression and showed that STAT3 rapidly activated the c-myc …

Dec 11, 2008 · By comparing Stat3 and c-Myc target genes with gene expression data from undifferentiated ES cells and embryoid bodies (EBs), we found that Stat3 binds active and …

Oct 26, 2021 · Our data suggest that rapamycin acts directly on STAT3 to decrease its transcrip-tion activity, providing important information for the pharmacological and pharmaceutical …

Collectively, we find that metabolic disruptions triggered by inflammatory signaling are associated with tumorigenesis via the STAT3/c-Myc axis. Keywords: colitis-associated cancer; …

Aug 12, 2024 · TTI-101 exhibited anticancer effects by targeting the STAT3/c-Myc signaling pathway, inducing cell cycle arrest, and promoting apoptosis in CC cells. These findings …