In this review, we focus on the role of YY1 in cancer biology, including its expression, function, regulation by other upstream factors, and some of its more significant downstream effectors.

Therefore, we examined YY1’s role in maintaining chromatin structure in G1E-ER4 cells 75, a mouse erythroblast line dependent on YY1 for long-term growth (Extended Data Fig. 1a). We created a YY1 auxin-inducible degron (YY1–AID) subline …

YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression.

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for " yin-yang."

Oct 26, 2024 · It has been shown that transcription factor YY1 binds to a conserved sequence at the 5′ end of the human L1 5′UTR and primarily dictates where transcription initiates. Putative YY1-binding motifs have been predicted in the 5′UTRs of …

Nov 28, 2005 · YY1 is a ubiquitous and multifunctional zinc-finger transcription factor (also known as δ, NF-E1, UCRBP, and CF1) member of the Polycomb Group protein family, a group of homeobox gene...

YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression.

Aug 29, 2024 · YY1 maintains a subset of E–P interactions in interphase and establishes an overlapping yet distinct set after mitotic exit.

Dec 14, 2017 · YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression.

Sep 30, 2020 · First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously expressed throughout mammalian cells. It regulates both transcriptional activation and repression, in a seemingly context-dependent manner.