A Unified Model for the Function of YTHDF Proteins in Regulating …
Jun 25, 2020 · Our study reveals a unified model of m 6 A function in which all m 6 A-modified mRNAs are subjected to the combined action of YTHDF proteins in proportion to the number …
- Author: Sara Zaccara, Samie R. Jaffrey
- Publish Year: 2020
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Context-Dependent Function…
Thus, we suggest a new model for the Ythdf readers function, in which there is …
The Mechanism Underlying R…
The YTH N<sup>6</sup>-methyladenosine RNA binding proteins (YTHDFs) …
Ythdf1 and Ythdf2 Are Associ…
The human YTH domain family (YTHDF) proteins are RNA-binding proteins that …
The YTHDF proteins display distinct cellular functions on m6A …
YTHDF proteins are main cytoplasmic 'reader' proteins of RNA N 6-methyladenosine (m 6 A) methylation in mammals. They are largely responsible for m 6 A-mediated regulation in the cell …
Context-dependent functional compensation between Ythdf m6A …
Oct 1, 2020 · Thus, we suggest a new model for the Ythdf readers function, in which there is profound dosage-dependent redundancy when all three readers are equivalently coexpressed …
- Author: Lior Lasman, Vladislav Krupalnik, Sergey Viukov, Nofar Mor, Alejandro Aguilera-Castrejon, Dan Schnei...
- Publish Year: 2020
- Studies of Ythdf M6A
m6A-binding YTHDF proteins promote stress granule formation
May 25, 2020 · Here, we show that m 6 A-modified mRNAs are enriched in SGs, and that m 6 A-binding YTHDF proteins are critical for SG formation. Depletion of YTHDF1/3 inhibits SG …
- Author: Ye Fu, Xiaowei Zhuang, Xiaowei Zhuang
- Publish Year: 2020
A neural m6A/Ythdf pathway is required for learning and memory …
Mar 5, 2021 · Here, we used Drosophila melanogaster to study N 6 -methyladenosine (m 6 A), the most abundant modification of mRNA. Proteomic and functional analyses confirm its nuclear …
- Author: Lijuan Kan, Stanislav Ott, Brian Joseph, Brian Joseph, Eun Sil Park, Wei Dai, Ralph E Kleiner, Adam ...
- Publish Year: 2021
A Unified Model for the Function of YTHDF Proteins in …
Jun 25, 2020 · Our study reveals a unified model of m 6 A function in which all m 6 A-modified mRNAs are subjected to the combined action of YTHDF proteins in proportion to the number of m 6 A sites. Methylation of adenosine in mRNA to …
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Targeting m6A binding protein YTHDFs for cancer therapy
Jul 15, 2023 · YT521-B homology domain family (YTHDF) is a class of m 6 A binding proteins, including YTHDF1, YTHDF2 and YTHDF3. In recent years, the modification of m 6 A and the …
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the …
1 day ago · The YTHDF family proteins, including YTHDF1, YTHDF2, and YTHDF3, are well-known m 6 A readers that have been implicated in mediating the effects of m 6 A in the …
The roles and mechanisms of the m6A reader protein …
Dec 3, 2021 · YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A). YTHDF1 regulates target gene expression by promoting translation or regulating the stability of mRNA. YTHDF1 plays an important …
Multivalent m6A motifs promote phase separation of …
Aug 6, 2019 · To study whether multivalent m 6 A regulates phase separation of YTHDFs in cells, we transfected RNA oligos with varying number of m 6 A RNA motifs into HEK293 cells and detected endogenous...
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