YAP antagonizes innate antiviral immunity and is targeted for
May 8, 2017 · In the present study, we identified YAP as a negative regulator of innate immunity to RNA and DNA viruses. YAP interacted with IRF3 and impaired the formation of IRF3 dimers and...
Targeting IRF3 as a YAP agonist therapy against gastric cancer
Feb 5, 2018 · In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric cancer; the expression of both IRF3 and YAP is up-regulated and prognosticates patient survival.
Targeting IRF3 as a YAP agonist therapy against gastric cancer
In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric cancer; the expression of both IRF3 and YAP is up-regulated and prognosticates patient survival.
The Crosstalk Between Hippo-YAP Pathway and Innate Immunity
We found YAP interacted with IRF3, a critical transcription factor in innate immunity, and prevented its dimerization and nuclear translocation, which further reduced the production of IFN-β and ISGs in response to virus infection.
microRNA-365 inhibits YAP through TLR4-mediated IRF3 …
Nov 13, 2024 · IRF3 is a well-defined signal transduction factor/transcription factor that is essential for the innate antiviral response. IRF3 promotes the nuclear translocation and activation of YAP by interacting with YAP and TEAD4 in the nucleus, thereby promoting the …
In this study, we discovered IrF3 as an agonist of Yes-associated protein (YAP). the expression of IrF3 is positively correlated with that of YAP and its target genes in gastric cancer;...
Hippo interferes with antiviral defences - Nature Cell Biology
Mar 31, 2017 · Activation of the Hippo pathway by starvation or cell–cell contact induces YAP/TAZ phosphorylation and its subsequent degradation allows TBK1 association with IKKɛ, to activate IRF3-mediated...
microRNA-365 inhibits YAP through TLR4-mediated IRF3 …
Nov 13, 2020 · IRF3 is a well-defined signal transduction factor/transcription factor that is essential for the innate antiviral response. IRF3 promotes the nuclear translocation and activation of YAP by interacting with YAP and TEAD4 in the nucleus, thereby promoting the …
YAP antagonizes innate antiviral immunity and is targeted for …
YAP deficiency resulted in enhanced innate immunity, a diminished viral load, and morbidity in vivo. YAP blocked dimerization of the transcription factor IRF3 and impeded translocation of IRF3 to the nucleus after viral infection.
Targeting IRF3 as a YAP agonist therapy against gastric cancer
Jan 16, 2018 · In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric cancer; the...