Hyperpolarized 129 Xe gas magnetic resonance imaging (MRI) is a medical imaging technique used to visualize the anatomy and physiology of body regions that are difficult to image with standard proton MRI.

Functional imaging today offers a rich world of information that is more sensitive to changes in lung structure and function than traditionally obtained pulmonary function tests. Hyperpolarized helium (3He) and xenon (129Xe) MR imaging of the lungs ...

In particular, the introduction of inhaled hyperpolarized (HP) noble gases – specifically xenon-129 (129 Xe) and helium-3 (3 He) – enhances the signal in the lung air spaces sufficiently to enable breath-held images of ventilation with MRI.

Hyperpolarized xenon-129 MRI (129XeMRI) has emerged as a powerful tool in the identification, evaluation, and assessment of disease endotyping and in response to interventions for a myriad of pulmonary diseases.

Oct 5, 2023 · This research culminated in the launch of the Xenon-129 MRI Clinical Trials Consortium in 2015, which began exploring the potential of hyperpolarized Xe gas imaged via radiation-free magnetic resonance imaging (MRI) as a standardized tool at other sites.”

Hyperpolarized 129 xenon gas magnetic resonance imaging (129 Xe MRI) provides an incredibly detailed view of pulmonary function — and, in doing so, appears to hold tremendous clinical promise.

May 26, 2022 · Inhaled during a subject's normal tidal breathing, MRI with the hyperpolarized gases — isotopes of helium (3He) and xenon (129Xe) — dramatically increases the sensitivity and contrast of pulmonary MRI and offers a reliable method to detect pulmonary disease.

Jan 6, 2023 · XENOVIEW, prepared from the Xenon Xe 129 Gas Blend, is a hyperpolarized contrast agent indicated for use with MR imaging for evaluation of lung ventilation in adults and pediatric patients aged 12 years and older.

Jul 26, 2022 · Many of us working with hyperpolarized (HP) xenon 129 (129 Xe) MRI have been frustrated by the lack of progress made at translating this research modality into clinical practice, particularly because of its unique scope to provide both …

Dec 12, 2024 · Hyperpolarised xenon-129 MRI (HPX-MRI) is a non-invasive, ionising-free imaging modality that can provide functional measurements of ventilation and diffusion within the lung.