XPO1 - Wikipedia
Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.
The nuclear export protein XPO1 — from biology to targeted …
Nov 10, 2020 · The nuclear export protein exportin 1 (XPO1) is crucial for the maintenance of cellular homeostasis as it mediates the transport of >200 proteins, many of which are tumour …
XPO1 Gene - GeneCards | XPO1 Protein | XPO1 Antibody
Mar 30, 2025 · XPO1 (Exportin 1) is a Protein Coding gene. Diseases associated with XPO1 include Primary Mediastinal Large B-Cell Lymphoma and Influenza. Among its related …
The nuclear export protein XPO1 provides a peptide ligand for …
Aug 23, 2024 · XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules …
Targeting XPO1 enhances innate immune response and inhibits …
We show that XPO1 inhibition with KPT-8602 and by shRNA knockdown significantly reduces infectious virions by inhibiting viral gene expression. XPO1 inhibition induces p62 nuclear …
XPO1 serves as a prognostic marker involving AKT/MAPK/TGFBR1 …
Aug 24, 2024 · Exportin 1 (XPO1) is a nuclear export protein that facilitates the transportation of various substances. XPO1 promotes tumor development as a poor prognostic factor in a …
Therapeutic targeting of exportin-1 beyond nuclear export
Dec 5, 2024 · Here, we discuss the canonical model of nuclear export and XPO1’s emergence as an anticancer target. We also spotlight the key evidence for underappreciated XPO1 functions …
Targeting XPO1 enhances innate immune response and inhibits
Jan 4, 2021 · These results illustrate a novel mechanism by which XPO1 mediates innate immune response and KSHV replication, and identify XPO1 as a potential therapeutic target and KPT …
7514 - Gene ResultXPO1 exportin 1 [ (human)] - National Center …
HMGB2-induced calreticulin translocation required for immunogenic cell death and ferroptosis of cancer cells are controlled by the nuclear exporter XPO1. Exportin 1 governs the …
XPO1-dependent nuclear export as a target for cancer therapy
Jun 1, 2020 · Suppression of XPO1-mediated nuclear export, therefore, presents a unique therapeutic strategy. In this review, we summarize the physiological functions of XPO1 as well …