Nov 8, 2018 · In both human and animal AAA tissues, a smooth muscle cell phenotypic switch was confirmed, as manifested by the downregulation of SM22α and α-SMA (α-smooth muscle …

Here, we identified that SM22 α loss contributed to apoptosis of VSMCs via activation of macrophages. Firstly, deficiency of SM22 α enhanced the interaction of VSMCs with …

Feb 1, 1996 · Abstract SM22α is a calponin-related protein that is expressed specifically in adult smooth muscle. To begin to define the mechanisms that regulate the establishment of the …

Feb 1, 2007 · SM22alpha is a 22-kDa cytoskeletal protein that is exclusively expressed in smooth muscle cells. We investigated the localization of SM22alpha at mRNA and protein levels, and …

SM22 alpha is a calponin-related protein that is expressed specifically in adult smooth muscle. To begin to define the mechanisms that regulate the establishment of the smooth muscle lineage, …

Aug 30, 2018 · For this purpose, we crossbred Igf1r -floxed mice with SM22α (smooth muscle protein 22α)-Cre knockin (SM22α-CreKI) mice, both nullizygous for the Apoe gene (Apoe −/−), …

Approach and Results- We generated Apoe -/- mice with IGF1R (IGF-1 receptor) deficiency in SMC and fibroblasts (SM22α [smooth muscle protein 22 α]-CreKI/IGF1R-flox mice).

We generated Apoe −/− mice with IGF-1 receptor (IGF-1R) deficiency in SMC and fibroblasts (SM22α-CreKI/IGF1R-flox mice). IGF-1R was decreased in the aorta and adventitia of SM22α …

SM22α (smooth muscle 22α) has a vital role in maintaining the smooth muscle cell phenotype and is downregulated in AAA. However, whether manipulation of the SM22α gene influences the …

To examine the molecular mechanisms that regulate SMC-specific gene expression, we have isolated and structurally characterized the murine SM22a gene. SM22a is a 6.2-kilobase single …