VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is broadly expressed in many different tissues. VKORC1 is …

The VKORC1 gene encodes the VKORC1 (vitamin K epoxide reductase) protein, which is a key enzyme in the vitamin K cycle [1, 2]. VKORC1 is a 163 amino acid integral membrane protein …

gene polymorphism in people with warfarin sensitivity, known as VKORC1A, changes a single DNA building block (nucleotide) in an area near the gene, which controls the production of the …

Mar 30, 2025 · VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1) is a Protein Coding gene. Diseases associated with VKORC1 include Vitamin K-Dependent Clotting Factors, …

Genetic studies have shown that the VKORC1 gene extends over 5126 base pairs on human chromosome 16 and comprises three exons. Mutations in the VKORC1 gene causes …

Feb 8, 2025 · Gene ID: 79001, updated on 8-Feb-2025. This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive …

Vitamin K oxidoreductase (VKORC1) converts vitamin K epoxide into reduced vitamin K, which acts as the co-factor for the γ-carboxylation of several proteins, including coagulation factors …

Vitamin K epoxide, a by-product of the carboxylation of blood coagulation factors, is reduced to vitamin K by an enzymatic system possessing vitamin K epoxide reductase (VKOR) activity. …

Feb 5, 2004 · VKORC1 contains missense mutations in both human disorders and in a warfarin-resistant rat strain. Overexpression of wild-type VKORC1, but not VKORC1 carrying the …

Aug 25, 2008 · The protein encoded by the VKORC1 gene is the primary target of the drug warfarin, (Coumadin), a commonly used oral anticoagulant. Several VKORC1 SNPs have …