Visfatin is a newly discovered adipocyte hormone with a direct relationship between plasma visfatin level and type 2 diabetes mellitus. Visfatin binds to the insulin receptor at a site distinct from that of insulin and causes hypoglycaemia by reducing glucose release from …

Visfatin is an adipokine identified in 2004 and thus named for the suggestion that it would be predominantly produced and secreted in visceral fat. Visfatin is highly preserved across animal evolution. It has a molecular weight of 52 KDa and its gene encodes 491 aminoacids.

In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.

The significance of visfatin in the pathogenesis of IR and its associated consequences reflects the potential utility of visfatin as an early biomarker for IR in high-risk patients, especially obese adults, and as a biomarker for T2DM sequelae.

This review aims to provide a comprehensive overview of the pro-inflammatory and angiogenic actions of visfatin, with a focus on the pertinent signaling pathways whose dysregulation contributes to the pathogenesis of atherosclerosis.

Jan 21, 2005 · We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity.

Jan 21, 2005 · Visfatin, the newly characterized hormone secreted by visceral fat, binds to the insulin receptor at a site separate from insulin and acts as a natural insulin mimetic. Leptin activates AMPK, acts centrally and peripherally to regulate metabolism and to reduce food intake, and is reduced in individuals with rare genetic obesity disorders.

Nov 9, 2020 · In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.

Oct 23, 2024 · Visfatin is an adipokine which acts synergistically with insulin to increase glucose cellular uptake, stimulate glucose transfer to the muscle and adipose tissue and prevents hepatic glucose production.

Visfatin, also known as nicotinamide phosphoribosyltransferase or pre-B-cell colony-enhancing factor (PBEF), is an adipocytokine secreted by adipocytes, macrophages and inflamed endothelial tissue. Related reports have indicated a positive ...