035670 B6.Cg-Tg(VAV1-cre)1Graf/MdfJ Vav-Cre transgenic mice express Cre recombinase under the control of the human vav 1 oncogene ( VAV1 ) regulatory elements in all nucleated blood cells as well as hematopoietic stem cells.

Cre transgenic mice can be used to delete gene sequences flanked by loxP sites in specific somatic tissues. We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic and endothelial cells.

008610 B6.Cg- Commd10 Tg(Vav1-icre)A2Kio /J Vav-iCre transgenic mice have the mouse HS21/45 control regions directing expression of an optimized variant of Cre recombinase (iCre) to hematopoietic cells (and their progenitors), and may be useful for generating conditional mutations in hematopoietic cells. In Goodwin et al. 2019 Genome Res. 29: ...

Nov 7, 2013 · Vav-Cre. Vav is a guanine nucleotide exchange factor regulated by the Rho/Rac family of small G proteins (Lazer and Katzav, 2011). The constitutively active Vav-Cre mice have been commonly used to achieve gene deletion in the hematopoietic system.

This strain carries a mouse Vav1 gene promoter-driven improved Cre (iCre) expression element insertion. When H11-Alb-iCre mice are crossed with mice containing loxP sites, Cre recombinase-mediated loxP site sequence recombination is induced in the hematopoietic stem cells (HSCs) of …

We have generated mouse lines expressing Cre recombinase in hematopoietic tissues using the vav regulatory elements, or in lymphoid cells using the hCD2 promoter and locus control region (LCR).

Jan 1, 2003 · We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic and endothelial cells. In these animals, a Cre transgene is expressed...

Nov 7, 2002 · We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic and endothelial cells. In these animals, a Cre transgene is expressed under control of murine vav gene regulatory elements.

Vav-iCre expresses active Cre in fetal and adult hematopoietic stem cells and all descendants, hCD2-iCre in immature and mature B and T lymphocytes. To better characterize which hematopoietic cells contain hCD2-iCre activity, we compared EYFP fluorescence in hCD2-iCre+/- R26-stop-EYFP+/- and Vav-iCre+/- R26-stop-EYFP+/- mice.

6 days ago · To overcome these limitations, we generated a hematopoietic-specific Gba knockout model by crossing Gba fl/fl mice with Vav-Cre, enabling early deletion of Gba exons 8–11 in hematopoietic stem and progenitor cells. These mice were backcrossed to 129X1/SvJ and C57BL/6 J backgrounds, revealing that genetic background significantly influences ...