Factor VIII and von Willebrand factor ... - Wiley Online Library
Dec 29, 2009 · The interaction of factor VIII (FVIII) with von Willebrand Factor (VWF) is of direct clinical significance in the diagnosis and treatment of patients with haemophilia A and von …
von Willebrand factor modulates immune complexes and the …
Nov 3, 2023 · Here, we addressed the role of von Willebrand factor (VWF) as a modulator of anti-FVIII antibody effector functions and the FVIII-specific recall response in an HA mouse model. …
The factor VIII/von Willebrand factor complex: basic and …
Factor VIIII (FVIII) and von Willebrand factor (VWF) are two distinct but related glycoproteins that circulate in plasma as a tightly bound complex (FVIII/VWF). Their deficiencies or structural …
Mapping the interaction between factor VIII and von Willebrand factor ...
Aug 20, 2015 · The high-affinity, noncovalent association of factor VIII (FVIII) with von Willebrand factor (VWF) in the circulation protects FVIII from otherwise rapid clearance. 1,2 Quantitative …
The Association of Factor VIII With von Willebrand Factor
Factor VIII (FVIII) and von Willebrand factor (vWF) can be defined as the factors that correct the plasmatic defect in hemophilia A and von Willebrand's disease, respectively. Each is a …
Molecular determinants of the factor VIII/von Willebrand factor …
May 27, 2021 · VWF-D′ makes extensive interactions with FVIII; visualization of FVIII-a3 showcases a central role of sulfated Y1680 in binding VWF R816. The structure of BIVV001 …
Factor VIII Is Synthesized in Human Endothelial Cells, Packaged …
Human factor VIII (FVIII) functions as a cofactor for activated factor IX, and mutations in the FVIII gene (F8) result in hemophilia A. FVIII in plasma is proteolyzed and/or pinocytosed unless it is …
Life in the shadow of a dominant partner: the FVIII-VWF …
Several novel recombinant FVIII (rFVIII) therapies for hemophilia A have been in clinical development, which aim to increase the half-life of FVIII (∼12 hours) and reduce dosing …
Patterns of expression of factor VIII and von Willebrand factor by ...
von Willebrand factor and FVIII are coexpressed in postcapillary high endothelial venules but not in most other ECs. Circulating factor VIII (FVIII) is derived from liver and from extrahepatic …
The association of factor VIII with von Willebrand factor
The extracellular association of FVIII with vWF may be necessary for efficient secretion of FVIII from its cell of origin. The thermodynamics, kinetics, and nature of the molecular contacts …