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See all on Wikipediavon Willebrand factor - Wikipedia
Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and … See more
Synthesis
VWF is a large multimeric glycoprotein present in blood plasma and produced constitutively as ultra … See moreHereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing See more
Von Willebrand Factor has been shown to interact with Collagen, type I, alpha 1.
Recently, It has been reported that the cooperation and … See moreVWF is named after Erik Adolf von Willebrand, a Finnish physician who in 1926 first described a hereditary bleeding disorder in families from Åland. Although von Willebrand did … See more
Wikipedia text under CC-BY-SA license Role of von Willebrand factor in the haemostasis - PMC
von Willebrand factor (VWF) is an adhesive and multimeric glycoprotein that found its historical origin in 1924, when the Finnish physician Erik von Willebrand first reported a family with a …
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von Willebrand Factor : A Marker of Endothelial Damage?
Sep 1, 1998 · Von Willebrand factor (vWF), a large glycoprotein encoded by a gene on chromosome 12, is synthesized by vascular endothelial cells and circulates in human plasma …
- Author: Pier Mannuccio Mannucci
- Publish Year: 1998
von Willebrand factor biosynthesis, secretion, and clearance ...
Mar 26, 2015 · In this review, an update on our current knowledge on VWF biosynthesis, secretion, and clearance is provided and we will discuss how they can be affected by the …
- Author: Peter J. Lenting, Olivier D. Christophe, Cécile V. Denis
- Publish Year: 2015
von Willebrand factor levels in the diagnosis of von …
Dec 30, 2021 · We systematically reviewed the accuracy of diagnostic tests using different cutoff values of von Willebrand factor antigen (VWF:Ag) and platelet-dependent von Willebrand factor (VWF) activity assays in the diagnosis of VWD.
The future of siRNA-mediated approaches to treat von Willebrand …
Jan 29, 2025 · In the field of VWD, small-interfering RNAs (siRNAs) have been explored through various strategies to improve disease phenotypes. These different approaches are discussed …
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Small interfering RNA–mediated allele-selective silencing of von ...
Oct 12, 2023 · Inhibiting VWF gene expression through allele-selective silencing of VWF with small interfering RNAs (siRNAs) could be a personalized approach to specifically inhibit …
Von Willebrand factor as a thrombotic and inflammatory mediator …
The endothelial exocytosis of high-molecular-weight multimeric von Willebrand factor (vWF) may occur in critical illness states, including trauma and sepsis, leading to the sustained elevation …
Von Willebrand Factor: Structure and Function
Von Willebrand factor (vWF) is an adhesive, multimeric glycoprotein present in plasma, platelets, and subendothelium, which has two main functions: (1) it serves as a carrier for factor VIII and (2) it plays a crucial role in platelet …
High von Willebrand Factor Levels Increase the Risk of …
Sep 21, 2006 · Methods— In a case-control study of 124 first-ever ischemic stroke patients and 125 age- and sex-matched controls, we studied vWF antigen (vWF:Ag), vWF ristocetin cofactor activity (vWF:RCo), ADAMTS13 activity, the …
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