Von Willebrand Factor (vWF) is a large glycoprotein with a broad range of physiological and pathological functions in health and disease. While vWF is critical for normal hemostasis, vascular integrity and repair, quantitative and qualitative ...

Sep 1, 1998 · Von Willebrand factor (vWF), a large glycoprotein encoded by a gene on chromosome 12, is synthesized by vascular endothelial cells and circulates in human plasma at concentrations of 10 μg/mL. 1 In plasma, vWF forms a noncovalent complex with coagulation factor VIII, the protein encoded by a gene on the X chromosome that is deficient or ...

Dec 30, 2021 · We systematically reviewed the accuracy of diagnostic tests using different cutoff values of von Willebrand factor antigen (VWF:Ag) and platelet-dependent von Willebrand factor (VWF) activity assays in the diagnosis of VWD.

Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion.

Mar 26, 2015 · In this review, an update on our current knowledge on VWF biosynthesis, secretion, and clearance is provided and we will discuss how they can be affected by the presence of protein defects.

Jan 27, 2022 · We here describe the development and characterization of Microlyse, a fusion protein consisting of a high-affinity V H H targeting the CT/CK domain of VWF and the protease domain of uPA, for localized plasminogen activation on microthrombi.

Dec 15, 2011 · Current antithrombotics used to treat or prevent cerebral ischemia are only moderately effective or bear an increased risk of severe bleeding. von Willebrand factor (VWF) has long been known to be a key player in thrombus formation at sites of vascular damage.

Jul 4, 2018 · von Willebrand factor (VWF) is a large, multimeric protein, playing a central role in platelet adhesion and primary haemostasis. The level of VWF is increased in patients with cirrhosis and correlates with the severity of the disease.

Von Willebrand factor (vWF) is an adhesive, multimeric glycoprotein present in plasma, platelets, and subendothelium, which has two main functions: (1) it serves as a carrier for factor VIII and (2) it plays a crucial role in platelet adhesion to subendothelium, acting as a “bridge” between platelet membrane glycoprotein (GP) Ib and GP IIb ...

The relationship between von Willebrand factor antigen (VWF:Ag), von Willebrand factor propeptide (VWFpp), VWFpp/VWF:Ag ratio, ADAMTS13 activity and micro-embolic signal (MES) status in carotid stenosis is unknown.