The enzyme urate oxidase (UO), uricase or factor-independent urate hydroxylase, absent in humans, catalyzes the oxidation of uric acid to 5-hydroxyisourate: [4] Uric acid + O 2 + H 2 O → 5-hydroxyisourate + H 2 O 2

In mammals, uricase is the primary enzyme that converts uric acid to allantoin, a more water-soluble form. This comparative biology approach paved the road for developing the recombinant form of uricase to treat advanced tophaceous gout and prevent uricosuria in treating certain hematological and solid tumor malignancies [8,9,10,11]. Currently ...

Sep 8, 2023 · In species other than humans, uricase (urate oxidase) converts urate to allantoin, which is more soluble in urine than uric acid. Exogenic uricases are an exciting therapeutic option for patients...

Due to the fact that uricase is completely foreign to the human immune system and our uricase is microbial in origin, we screened the engineered Arthrobacter globiformis uricase protein for T-cell immunogenicity in 202 PBMC donor samples selected to represent a cross section of HLA-DRB1 frequencies. Surprisingly, in these assays only 1 donor ...

Dec 21, 2016 · In canines, an 85% reduction in serum uric acid levels was observed with a single subcutaneous injection. This PEGylated, non-immunogenic uricase has the potential to provide meaningful benefits to patients with gout.

Nov 14, 2024 · In this study, we constructed engineered macrophages that stably expressed uricase, which might serve as a promising alternative to the direct injection of uricases. Materials and Methods : Engineered macrophages RAW264.7 cells were injected intravenously to treat hyperuricemic KM mice.

Uricase is an enzyme to get rid of uric acid. Humans don’t have it. See uricase-based gout treatment that removes uric acid the fastest way.

In species other than humans, uricase (urate oxidase) converts urate to allantoin, which is more soluble in urine than uric acid. Exogenic uricases are an exciting therapeutic option for patients with gout.

Jul 18, 2018 · The European League against Rheumatism, in its most recent guidance on gout issued in 2016, advocates the use of pegloticase for refractory gout (3). The uricase has a similar indication in the USA and is approved by the USA Food and …

Uricase is an enzyme that plays a crucial role in purine metabolism. It catalyzes the oxidation of uric acid, a waste product of purine catabolism, to allantoin, a more soluble and less toxic compound. Uricase is found in various organisms, including bacteria, fungi, plants, and animals.