U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee, Virginia, Kentucky, and Indiana. The highway runs for 941 miles (1,514 km) from Fort Fisher, North Carolina, to US 20 in Michigan City, Indiana.

In the U.S. state of North Carolina, US 421 travels 328 miles (528 km) from its southern terminus at Fort Fisher to the Tennessee state line near the community of Zionville, North Carolina. US 421 traverses the state from east to west travelling from the coastal plains to Appalachian Mountains.

U.S. Route 421 (US 421) enters Indiana from Kentucky, proceeding northwest to Indianapolis, joining Interstate 465, and then continuing northwest to Michigan City. US 421 winds through the southern part of Indiana as it runs from Madison, in the southeastern part of the state, to

U.S. Route 421 traverses approximately 328 miles (528 km) across North Carolina; from Fort Fisher, on a peninsula between the Atlantic and Cape Fear River, to the Tennessee state line near the community of Zionville.

Sep 23, 2024 · US route 421 has endpoints in Michigan City (Indiana) and Ft. Fisher (North Carolina), with historic termini in Bristol, Cumberland Gap, Wilmington, Greensboro, and Boone. US Ends .com Home

Heading toward Deep Gap on US 421, New River peeks out from the trees as the Blue Ridge Mountains come into the foreground for enviable views full of hardwood and mixed forest that in the chilly air of autumn burst with pops of red and yellow along the mountainsides.

U.S. 421 traverses the state of North Carolina from the Blue Ridge Mountains and Boone east to the Piedmont Triad and the port city of Wilmington.

Dec 30, 2016 · US 421 appeared in 1930 as an addition to NC 60, running only from Boone to Greensboro. In 1932, US 421 replaced US 321 from Boone to Tennessee and was also extended southeast with NC 60 to Wilmington.

U.S. Route 421 (US 421) is a north–south United States highway that runs for 43.4 miles (69.8 km) in East Tennessee, connecting the cities of Mountain City and Bristol. The entire route is overlapped with SR 34, save for approximately a half mile between US 11E/US 19 and the Virginia State Line.

As the US 421 Scenic Byway travels through the Blue Ridge Mountains, it offers sweeping views of the valleys, woodlands, and mountains between the towns of Deep Gap and Boone. It also runs near the home of multiple Grammy Award winner and cultural icon Doc Watson.