Type II PKSs behave very similarly to type I PKS but with one key difference: Instead of one large megaenzyme, type II PKSs are separate, monofunctional enzymes.

Type I PKSs are multifunctional enzymes organized into modules, each of which harbors a set of distinct domains responsible for the catalysis of one cycle of polyketide chain elongation.

Here, we used the web tool NaPDoS2 to assess type I polyketide synthase (PKS) diversity and distributions by detecting and classifying ketosynthase (KS) domains across 137 …

Jun 1, 2000 · Modular polyketide synthases (type-I PKSs) are large multienzyme complexes that build macrocyclic polyketides by the condensation of acetates, propionates and butyrates; the …

However, more and more bacterial modular PKSs fail to conform to the canonical rules, and a particularly noteworthy group of non-canonical PKSs is the bacterial iterative type I PKSs. This …

Mar 26, 2020 · Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which can act either iteratively or via an assembly-line mechanism. Domains in the …

Feb 21, 2003 · Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains a β-ketoacyl synthase, an …

Sep 29, 2015 · We have solved crystal structures of seven AT-less type I PKS KS domains that represent various sequence clusters, revealing insight into the large structural and subtle …

Feb 20, 2019 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to present …

Jun 6, 2014 · Type I modular polyketide synthases (PKSs) are enzyme assembly lines for the synthesis of chemically diverse polyketide natural products that form the basis for nearly one …