Trilostane, also known as 4α,5-epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile, is a synthetic androstane steroid and a derivative of 5α-reduced androstane derivatives like 3α-androstanediol, 3β-androstanediol, and dihydrotestosterone. [6] Trilostane is prepared from testosterone in a four-step synthesis. [citation needed]

Jun 13, 2024 · Trilostane is used to help treat hyperadrenocorticism in dogs, otherwise known as Cushing’s disease. Your veterinarian will decide whether it’s right for your dog, but here are some things to know before you consider this medication.

What is trilostane? Trilostane (brand names: Vetoryl®, Desopan®, Modrastane®, or Modrenal®) is used for the treatment of hyperadrenocorticism in dogs (Cushing’s disease) and cats and Alopecia X in dogs. How is trilostane given? Trilostane is given …

VETORYL Capsules are indicated for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs. As with all drugs, side effects may occur.

Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase, the enzyme essential for synthesis of cortisol and all other steroids. Trilostane is reported to be safe and effective in the treatment of pituitary-dependent hyperadrenocorticism (HAC), adrenal-dependent HAC, …

Mar 21, 2023 · Trilostane has been prescribed for over 20 years to treat pets with Cushing's disease. Learn what it is, how it works, and whether it might be right for your pet.

Jul 14, 2022 · Trilostane is a synthetic enzyme inhibiting drug that is used to treat Cushing’s Disease in dogs and cats. Trilostane decreases the production of excessive cortisol hormone by the adrenal gland. This disease is not cured by trilostane but can be managed successfully.

Mar 2, 2025 · Trilostane (4α,5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone.

Jul 23, 2024 · Trilostane for dogs. Trilostane is a drug which is used to treat hyperadrenocorticism, also known as Cushing's disease in dogs. We look at the uses, dosage and side effects of trilostane for dogs.

Trilostane (4α,5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone.