Structural and functional evidence of bacterial antiphage
Jun 4, 2020 · The Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB.
Activation of Thoeris antiviral system via SIR2 effector filament ...
Feb 21, 2024 · In the Thoeris system, a Toll/interleukin-1 receptor (TIR)-domain protein, ThsB, acts as a sensor that synthesizes an isomer of cyclic ADP ribose, 1′′−3′ glycocyclic ADP ribose (gcADPR), which is...
Nucleotide Immune Signaling in CBASS, Pycsar, Thoeris, and …
In this article, we review the molecular mechanisms controlling nucleotide immune signaling in four major families of antiphage defense systems: CBASS, Pycsar, Thoeris, and type III CRISPR immunity.
Boehringer Ingelheim Partners with Thoeris | BI US
Boehringer Ingelheim will be commencing a new collaboration with Thoeris GmbH with the goal of advancing a first-in-class approach for the treatment of urea cycle disorders (UCDs) independent of the underlying monogenetic cause.
Antiviral activity of bacterial TIR domains via immune ... - Nature
Dec 1, 2021 · TIR domains have also been shown to be involved in a bacterial anti-phage defence system called Thoeris 6, but the mechanism of Thoeris defence remained unknown. Here we show that phage...
Structure-guided discovery of viral proteins that inhibit host …
Mar 20, 2025 · Focusing on Thoeris and CBASS, bacterial defense systems that are the ancestors of eukaryotic Toll/interleukin-1 receptor (TIR) and cyclic GMP-AMP synthase (cGAS) immunity, we discover seven families of Thoeris and CBASS inhibitors, encompassing thousands of genes widespread in phages.
Structural characterization of macro domain–containing Thoeris ...
Jun 26, 2024 · Thoeris defense systems protect bacteria from infection by phages via abortive infection. In these systems, ThsB proteins serve as sensors of infection and generate signaling …
TIR signaling activates caspase-like immunity in bacteria
Jan 30, 2025 · Together, these results demonstrate that the caspase-like protein is activated by a small molecule specifically produced by the TIR-domain protein during phage infection. We therefore name this defense system type IV Thoeris.
Scientists have determined the structure of the previously unknown active SIR2 effector of the bacterial defense system Thoeris (named after the Egyptian goddess who protects childbirth and...
A bacterial TIR-based immune system senses viral capsids to
Jul 29, 2024 · How bacterial TIRs recognize phage infection is not known. Here we describe the sensing mechanism for the staphylococcal Thoeris defense system, which consists of two TIR domain sensors, ThsB1 and ThsB2, and the effector ThsA.