Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. [5][6]

Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres. [3][4] TERC serves as a template for telomere replication (reverse transcription) by telomerase.

Another major component of the telomerase complex is telomerase RNA component (TERC). It is an RNA sequence, which functions as a template for synthesis of telomeres by TERT.

Jan 26, 2024 · As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in its promoter and phosphorylation respectively...

The telomerase RNP is minimally composed of the telomerase reverse transcriptase (TERT) protein and the integral telomerase RNA (TR) (Fig. 1A and 1B). To extend telomeres, telomerase binds to the 3’ single-stranded DNA tail and uses a short segment within TR as a template for a TERT-catalyzed reverse transcription reaction (Fig. 1C).

Full-length TERT and the 322-amino-acid TERT RNA binding domain both bind telomerase RNA with high apparent affinity and similar specificity. We also identified a 288-amino-acid region of hTERT that is necessary and sufficient for association with hTR in vivo.

Jun 3, 2021 · Single molecule RNA FISH reveals that nuclear TERT transcripts uniformly and robustly retain specific introns. Our data suggest that the splicing of TERT retained introns occurs during...

Aug 15, 2011 · The telomerase holoenzyme includes a unique reverse transcriptase [telomerase reverse transcriptase (TERT)], an essential RNA (TR), and several species-specific proteins required for proper function in vivo (27 – 29).

The telomerase reverse transcriptase (TERT) is the essential protein component of the telomerase ribonucleoprotein. TERT is composed of four structural domains: telomerase essential N-terminal (TEN), telomerase RNA binding domain (TRBD), reverse transcriptase (RT), and C-terminal extension (CTE).

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat.