Nov 10, 2016 · We developed fully biodegradable/metabolizable nanosystem based on polymer surfactant-stabilized thermoresponsive solid lipid nanoparticles with non-covalently bound photosensitizer temoporfin (T-SLNP) with particle size below 50 nm.

Visualize mRNA-loaded (left) and unloaded (right) lipid nanoparticle samples with cryo-TEM imaging. Cryotransmission electron microscopy (cryo-TEM) has long played a pivotal role in the characterization of lipid nanoparticles.

Nov 1, 2023 · In this study, glioma cell membranes are used to encapsulate indocyanine green (ICG) loaded nanoparticles (SLNP/ICG), termed as SLNP/ICG@M for targeted photodynamic therapy (PDT) against glioma. Cell membrane modification significantly enhances cellular uptake of SLNP/ICG@M in homologous glioma cells in vitro and tumor distribution in vivo.

Transmission electron microscopy (TEM) observations revealed that sLNP (CRI) had a typical spherical structure (Figure 3B). The average size and surface charge, both measured using a Zetasizer Nano ZS, were 100 ± 20 nm (Figure 3D) and 37.6 mV (Figure 3E), respectively.

Oct 4, 2021 · The physicochemical characterization of BSE loaded solid lipid nanoparticles (BSE-SLNp) has been analyzed using Zetasizer, FT-IR, and TEM. The BSE-SLNp showed an average diameter of 20–110 nm on the day of preparation and it …

The ultrastructural morphology of the SLNPs and their siRNA-based nanocomplexes (at optimum binding ratios) were examined by transmission electron microscopy (TEM) using a Jeol T-1010 TEM (JEOL Ltd.; Tokyo, Japan).

Sep 5, 2024 · In this study, we demonstrated that the optimal polyethylene glycol (PEG) shielding and mannose ligand densities per lipid nanoparticle (LNP) can differ remarkably between cellular uptake to macrophages in vitro and spleen accumulation after systemic administration in vivo.

Nov 10, 2016 · We developed fully biodegradable/metabolizable nanosystem based on polymer surfactant-stabilized thermoresponsive solid lipid nanoparticles with non-covalently bound photosensitizer temoporfin (T-SLNP) with particle size below 50nm.

SLNPs were successfully prepared with smaller particle size of 67.63 ± 5.02 nm, higher DL% of 5.58 ± 0.41% and PDI of 0.159 ± 0.018 ( Fig. S1 and Table S1). The particle size and TEM image of...

The TEM & AFM analysis showed irregularly spherical morphology. In vitro release of SLNs was noted up to 48 h; whereas the pure drugs released completely within 3 hrs.