T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene. [5] [6] [7]

Mar 30, 2025 · TCL1A (TCL1 Family AKT Coactivator A) is a Protein Coding gene. Diseases associated with TCL1A include Leukemia and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of this gene is MTCP1.

Apr 12, 2023 · A genome-wide association study revealed that a common inherited polymorphism in the TCL1A promoter was associated with a slower expansion rate in clonal haematopoiesis overall, but the effect...

TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell survival, growth, and proliferation. It has also been identified as interacting with others major actors involved in B cells differentiation and regulation, including IL-10 production.

TCL1A expression delineates biological and clinical variability in B-cell lymphoma. Tcl1A unique set of molecules, Tcl1 and galectin-1, defines distinct B cell receptor signaling cascades, dictating survival and death of human naive and immunoglobulin M-positive (IgM+) memory B cells.

Jun 1, 2021 · TCL1A has first been identified as an oncogene, overexpression of which is associated to the development of T and B cell cancer. TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell …

Mar 23, 2023 · Downregulated CDC20 in CLL cells resembles the aneuploidy phenotype and is associated with more aggressive disease and cellular features. Proposed integrative model of oncogenic TCL1A through the promotion of genomic instability in malignant B-cells.

Oct 29, 2021 · Understanding how TCL1A is deregulated and how this can lead to tumor initiation and sustenance can help in future approaches to interfere in its oncogenic actions.

Aug 13, 2018 · Almost 30 years ago, Carlo Croce's group discovered the T-Cell Leukemia/Lymphoma 1A oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in fetal tissues and early developmental stage lymphocytes. Its expression is deregulated in chronic lymphocytic leukemia (B-CLL) and most lymphomas.

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t (14;14) (q11;q32); translocation t (7;14) (q35;q32); inversion inv (14) (q11;q32) that involves the T-cell receptor alpha/delta loci. Showing features for mutagenesis, natural variant. Greatly reduced binding to AKT1, AKT2 and AKT3.