“T cell factor 1” (HUGO gene name TCF7 [van de Wetering et al. 1991]) and “lymphoid enhancer factor 1” (HUGO gene name LEF1 [Travis et al. 1991; Waterman et al. 1991]) were discovered in T and B cells.

Transcription factor 7 (TCF7) plays an essential role in Wnt signaling by interacting with β-catenin. Emerging evidence demonstrates that overexpression of TCF7 promotes progression or correlates with poor progression in several types of cancers, ...

Mar 3, 2023 · Here, we demonstrate that transcriptional repression exerted by Wnt/TCF7L1 promotes PE differentiation of mESCs and in preimplantation inner cell mass.

T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling pathway. The mammalian TCF/LEF family comprises four nuclear factors designated TCF7, LEF1, TCF7L1, and TCF7L2 (also known as TCF1, LEF1, TCF3, and TCF4, respectively).

Nov 13, 2018 · Western blots for detection of TCF7, LEF1, TCF7L1, TCF7L2 and β‐catenin (B′) proteins in wild‐type (WT) and knockout (K.O.) cells. Uncropped version of the same Western blots is shown in Fig EV1.

Mar 20, 2020 · Our results show that the vital necessity for TCF7L2 in healthy intestinal cells is broadly lost in the course of colorectal carcinogenesis. Even though TCF7L2-negative cells exhibit delayed...

Aug 20, 2015 · TCF7 interacts with multiple proteins and target genes (e.g. CD3E, β-catenin, TCF7L2, LEF-1, IL-17, IL-4, or Eomes) and is involved in several signal pathways (e.g. Wnt, FoxO1, Notch, or P21pathways) which are critical for lung diseases, especially the canonical Wnt/β-catenin pathway.

Jan 1, 2015 · TCF7, a WNT signaling-related gene, has been implicated as a critical factor in bone metastasis, and here we show that TCF7 is a direct target of miR-34a. In samples of prostate cancer patients, miR-34a levels are inversely correlated with TCF7 expression and a WNT dependent gene signature.

6 days ago · In TCF7L2 mutant livers, no changes in the expression of related Wnt transcription factors Tcf7 (Fig. 3H) and Lef1 (Fig. 3I) were observed. TCF7L2 inactivation eliminates zone 3-specific ...

Nov 27, 2024 · Wnt/β-catenin/transcription factor (TCF) transcriptional activity plays an integral role in colorectal cancer (CRC) carcinogenesis. However, to date, no drugs targeting this pathway are used in clinical practice owing to the undesirable and serious side effects.