Mar 24, 2025 · TTP can be immune-mediated, due to autoantibodies against ADAMTS13, or hereditary, due to pathogenic variants in the ADAMTS13 gene. This topic reviews the clinical …

Nov 30, 2018 · In patients with TTP, inhibitor tests may be useful for distinguishing immune-mediated from congenital TTP. In this article, we review the epidemiology, natural history, and …

Jan 15, 2025 · The initial evaluation of a patient with suspected thrombotic thrombocytopenic purpura (TTP) or another primary thrombotic microangiopathy (TMA) syndrome must focus on …

Apr 7, 2023 · Thrombotic thrombocytopenic purpura (TTP) is a medical/hematologic emergency, and all TTP patients should be placed in an intensive care unit (ICU) setting. An internist can …

Diagnosing thrombotic thrombocytopenic purpura (TTP) rapidly is critical and can be lifesaving. Learn how to differentiate TTP from other conditions.

Apr 8, 2021 · Complete blood count (CBC) findings in patients with thrombotic thrombocytopenic purpura (TTP) are usually as follows: Peripheral blood smears reveal moderate-to-severe …

Sep 24, 2024 · Thrombotic microangiopathy involves tiny clots forming within the microvasculature. This leads to erythrocyte fragmentation (which is termed MAHA: …

What blood tests will your doctor run to see if you may have TTP? The most important tests are platelet count and ADAMTS13 activity levels.

Hereditary thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman syndrome or congenital TTP (cTTP), is a rare blood condition associated with germline …

Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ …