Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. [5] [6] The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans.

This chapter focuses on TRPM8, describing what was known about cold signaling before the channel was cloned, how TRPM8 was identified as a cold sensor, and what advances have been made in our understanding of the molecular logic for cold sensation since its identification.

Oct 18, 2023 · Melastatin-like transient receptor potential (TRPM) channels are multifunctional cation channels with diverse biophysical and physiological characteristics. Eight family members have been...

Sep 5, 2020 · The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca 2+ homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the transient receptor potential (TRP) channel subfamilies and exploited so far to reach ...

Transient Receptor Potential Melastatin 8 (TRPM8) is a member of the TRP ion channel family; its major physiological activator is cold, and it is also activated by “cooling agents” such as menthol. TRPM8 is a well established physiological sensor of environmental cold temperatures.

Transient receptor potential melastatin 8 (TRPM8) channels play a central role in the detection of environmental cold temperatures in the somatosensory system. TRPM8 is found in a subset of unmyelinated (C-type) afferents located in the dorsal root (DRG) and trigeminal ganglion (TG).

May 30, 2007 · The menthol receptor TRPM8 is a strong candidate as a cold transducer, but its physiological importance has been questioned. A study of cold sensitivity in TRPM8 knockout mice has clarified...

Sep 5, 2019 · Here, we present cryo–electron microscopy structures of TRPM8 in ligand-free, antagonist-bound, or calcium-bound forms, revealing how robust conformational changes give rise to two nonconducting states, closed and desensitized.

Sep 5, 2020 · Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation …

Oct 19, 2023 · TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in...