TNF signaling drives myeloid-derived suppressor cell accumulation
Here we report that TNF signaling drives the peripheral accumulation of myeloid-derived suppressor cells (MDSCs). MDSCs expand extensively during inflammation and tumor …
The Function and Therapeutic Implications of TNF Signaling in …
In this review, we summarize the roles played by TNF-α in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs, and discuss the potential therapeutic effects of TNF-α …
TNF signaling drives myeloid-derived suppressor cell accumulation
Nov 1, 2012 · Here we report that TNF signaling drives the peripheral accumulation of myeloid-derived suppressor cells (MDSCs). MDSCs expand extensively during inflammation and tumor …
Genetic screen in myeloid cells identifies TNF-α autocrine ... - Nature
Sep 7, 2018 · Through screening of 217 genes, we found that autocrine secretion of TNF-α contributes to MDSC immunosuppressive activity through up-regulation of Nos2. The …
Genetic screen in myeloid cells identifies TNF-α autocrine …
Through screening of 217 genes, we found that autocrine secretion of TNF-α contributes to MDSC immunosuppressive activity through up-regulation of Nos2. The approach described …
Myeloid suppressor cells require membrane TNFR2 expression for ...
May 28, 2014 · TNF and TNF receptor type 2 (TNFR2) have been shown to be important for generation of myeloid-derived suppressor cells (MDSC). In order to analyze whether and how …
TNF Neutralization Results in the Delay of Transplantable Tumor …
Apr 19, 2016 · TNF is a critical factor for the induction, expansion, and suppressive activity of MDSCs. In this study, we evaluated the effects of systemic TNF ablation on tumor-induced …
Tumor Necrosis Factor-α Blocks Differentiation and Enhances …
Mar 21, 2013 · Here we showed that TNF-α exhibited a dual function during chronic inflammation: arresting differentiation of immature myeloid-derived suppressor cells (MDSCs) primarily via …
TNF signaling drives myeloid-derived suppressor cell accumulation …
Oct 15, 2012 · Here we report that TNF signaling drives the peripheral accumulation of myeloid-derived suppressor cells (MDSCs). MDSCs expand extensively during inflammation and tumor …
The Function and Therapeutic Implications of TNF Signaling in …
Nov 3, 2022 · TNF signaling pathways enhance the inhibitory effect of MDSCs on T cells. tmTNF activates the immunosuppressive function of MDSCs by activating NF-κB and p38 signaling …