TGF-β induced EMT and stemness characteristics are associated with ...
Jun 30, 2020 · Transforming growth factor-β (TGF-β) promotes tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT). EMT is often related with acquisition of …
TGF-beta-induced epithelial to mesenchymal transition
Although much less characterized, epithelial plasticity can also be regulated by TGF-beta-related bone morphogenetic proteins (BMPs), and BMPs have been shown to induce EMT or MET …
TGF-β and RAS jointly unmask primed enhancers to drive metastasis
Sep 6, 2024 · Transforming growth factor β (TGF-β) and RAS, signaling through SMAD and RAS-responsive element-binding protein 1 (RREB1), jointly trigger expression of EMT and …
TGF-β-induced epithelial to mesenchymal transition - PMC
In this review, we will discuss the induction of EMT in response to TGF-β, and focus on the underlying signaling and transcription mechanisms. Epithelial cells typically form sheets, tubes …
TGF-β–induced epithelial-to-mesenchymal transition ... - Science
Sep 30, 2014 · Transforming growth factor–β (TGF-β) triggers EMT. The core regulatory network of TGF-β–induced EMT is composed of two transcription factors (SNAIL1 and ZEB1), two …
TGF-β signaling and epithelial-mesenchymal transition in …
In this review, we focus on the novel insights into the roles of TGF-β-induced EMT in cancer progression and the underlying mechanisms that enable TGF-β to activate this epithelial …
TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer …
Jun 5, 2019 · In this review, we will consider the role of TGF-β signaling in cell cycle arrest, apoptosis, EMT and cancer cell metastasis. In particular, we will highlight recent insights into …
The Relevance of the TGF-β Paradox to EMT-MET Programs
The switch in TGF-β function is known as the “TGF-β Paradox,” whose manifestations are intimately linked to the initiation of epithelial-mesenchymal transition (EMT) programs in …
TGFβ-dependent Epithelial-Mesenchymal Transition
The transforming growth factor β (TGFβ) is involved in a whole range of bio logical functions, from cell growth to cell differentiation and apoptosis. The role of TGFβ in epithelial-mesenchymal …
TGF-β orchestrates fibrogenic and developmental EMTs via the …
Jan 8, 2020 · Transforming growth factor β (TGF-β) is a potent inducer of developmental and fibrogenic EMTs 4, 9, 10. Aberrant TGF-β signalling and EMT are implicated in the …
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