Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene. [5] [6] This protein is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its …

Mar 30, 2025 · TFR2 (Transferrin Receptor 2) is a Protein Coding gene. Diseases associated with TFR2 include Hemochromatosis, Type 3 and Hemochromatosis, Type 1. Among its related …

Aug 29, 2005 · TFR2-related hemochromatosis (TFR2-HC) is characterized by increased intestinal iron absorption resulting in iron accumulation in the liver, heart, pancreas, and …

The TFR2 gene provides instructions for making a protein called transferrin receptor 2. The main function of this protein is to help iron enter liver cells (hepatocytes).

Human TfR2, another receptor for Tf, is predominantly expressed in hepatocytes and erythroid precursors, and holo-Tf dramatically upregulates its expression. TfR2 forms a complex with …

TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron-saturation of Tf is high. To better understand the nature of these TfR-Tf interactions, a binding study with the full-length …

Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe 2 Tf). …

Dec 15, 2004 · Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis. In this …

TfR2 can bind iron-loaded transferrin (Tf) in the bloodstream, and hepatocytes treated with Tf respond with a 2-fold increase in hepcidin expression through stimulation of the bone …

Aug 17, 2024 · TFR2 regulates ferroptosis and enhances temozolomide chemo-sensitization in gliomas. Tong S, Hong Y, Xu Y, Sun Q, Ye L, Cai J, Ye Z, Chen Q, Tian DTong S, et al . Exp …