Follicular helper T (Tfh) cells are identified as a subset of CD4 + T helper cells, which is specialized in helping B cells in the germinal center reaction. Tfh cells express high levels of …

Jun 22, 2020 · Follicular helper T cells (T FH) provide key signals to antigen-specific B cells for the development of germinal center B (B GC) cells 1, 2. CD4 + T cells receiving T FH inductive …

Thpok (encoded by Zbtb7b) is an upstream regulator of Bcl6 by binding to intron 1 of Bcl6, and genetic ablation of Zbtb7b (Zbtb7b fl/fl Ox40-Cre) in CD4 + T cells interfered with Bcl6 and Maf …

Jan 1, 2025 · Our current review provides the molecular characteristics of human Tfh cells, the differentiation pathways of Tfh subsets, mechanisms by which Tfh subsets induce IgE and …

Feb 1, 2024 · We clarified the role of infiltrating GC-Tfh cells in lesions with TLOs by analyzing CD3 + T cells in SGs from patients with IgG4-RD (n = 6) using scRNA-seq (10x Genomics, …

Aug 29, 2023 · investigate CD4 1CXCR5 Bcl6 GC-Tfh cells in affected lesions from patients with IgG4-RD. Results: Infiltrating CD4 1CXCR5 Bcl6 Tfh cells were divided into 5 main clusters. …

Oct 15, 2017 · In this study, we first showed that a large number of Tfh (CD3 + CD4 + CXCR5 +) cells characterized by high expression levels of BCL6, PD-1, and ICOS had infiltrated …

This review focuses on advances in our understanding of Bcl6-mediated gene regulation of T FH functions, and the modulation of T FH by other TFs. These advances may have important …

Apr 6, 2015 · Here we defined the BCL6 cistrome in primary human germinal center Tfh cells to assess mechanisms of BCL6 regulation of CD4 T cells, comparing and contrasting BCL6 …

Sep 27, 2021 · Loss-of-function and gain-of-function experiments in CD4 + T cells revealed that BCL6 is required for T FH cell differentiation in vivo and for the development of germinal …