Dec 3, 2015 · Many studies on TEL-AML1 describe specific properties of the fusion protein, but a thorough understanding of its function is lacking. We exploited a pluripotent hematopoietic …

Nov 19, 2010 · TEL-AML1 (ETV6-RUNX1), the product of t (12;21) translocation, is the most common cytogenetic abnormality in childhood cancer, and is detected in 25–30% of precursor …

Jun 15, 1995 · We have characterized the recurrent t (12;21) (p12;q22) translocation present in human B-lineage acute leukemias. This translocation fused two genes, tel and AML1, that …

Jul 15, 2002 · TEL-AML1 is expressed from the t (12;21) chromosomal translocation inB-precursor acute lymphocytic leukemia (ALL). Creation of the TEL-AML1fusion disrupts one …

Apr 20, 2015 · Our study describes the modulation of IRF3 function by the TEL-AML1 fusion protein, and implicates the IFNα/β pathway as a potential target to improve disease management.

The t (12;21) translocation, which generates the TEL-AML1 (ETV6-RUNX1) fusion gene, is the most common structural chromosome change in childhood cancer and is exclusively …

Jul 15, 2002 · TEL-AML1 is expressed from the t (12;21) chromosomal translocation inB-precursor acute lymphocytic leukemia (ALL). Creation of the TEL-AML1fusion disrupts one …

Mar 16, 2009 · TEL (ETV6)-AML1 (RUNX1), generated by the t (12;21) chromosome translocation, is the most common chimeric fusion gene in childhood cancer, selectively …

May 24, 2004 · We discuss here the prenatal origins of the TEL/AML1 translocation as an initiating mutation, the role of TEL-AML1 in cellular transformation and the molecular …

Aug 15, 1999 · TEL-AML1 gene fusion derived by chromosomal translocation is a common acquired genetic lesion in pediatric cancer that is present in ∼25% of B-cell precursor acute …