Benchmarking of T cell receptor repertoire profiling methods …
Sep 7, 2020 · In this study, we systematically compared the results of nine commercial and academic TCRseq methods, including six rapid amplification of complementary DNA ends …
T-Cell Receptor Repertoire Sequencing and Its Applications: Focus …
Here, we provide an updated overview of TCR repertoire sequencing strategies, providers and applications to infectious diseases and cancer to guide researchers’ choice through the …
A current and future perspective on T cell receptor repertoire ...
T cell receptors (TCR) play a vital role in the immune system’s ability to recognize and respond to foreign antigens, relying on the highly polymorphic rearrangement of TCR genes. The …
Recognizing and Profiling T Cell Receptors - Crown Bio
Mar 5, 2019 · T cell receptors (TCR) play an important role in adoptive T cell therapy (ACT), an effective new treatment approach which induces durable regression of blood cancers. The …
Mapping the functional landscape of T cell receptor ... - Nature
Jan 6, 2021 · Many experimental and bioinformatics approaches have been developed to characterize the human T cell receptor (TCR) repertoire. However, the unknown functional …
Unified cross-modality integration and analysis of T cell receptors …
Apr 29, 2024 · UniTCR is presented as a novel and unified single-cell embedding method designed for the joint analysis of individual T cell gene expression profiles and their …
Overview of methodologies for T-cell receptor repertoire analysis
The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory …
Sequence analysis of T-cell repertoires in health and disease
Oct 30, 2013 · High-throughput TCR sequencing (TCR-seq) involves the use of next generation sequencing platforms to generate large numbers of short DNA sequences covering key …
T Cell Receptor Repertoire Sequencing | SpringerLink
Jul 25, 2020 · High-throughput sequencing promotes the studying in TCR repertoire. The chapter focuses on the whole process of TCR profiling, including DNA extraction, library construction, …
A SMARTer approach to T-cell receptor profiling - Takara Bio
Learn about a 5' RACE-based approach to TCR profiling that provides full-length sequence information for TCR-a and TCR-b variable regions.
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