TANK-binding kinase 1 - Wikipedia
TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is …
TBK1, a central kinase in innate immune sensing of nucleic
Jul 10, 2020 · TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to …
TBK1 Gene - GeneCards | TBK1 Protein | TBK1 Antibody
Mar 30, 2025 · TBK1 (TANK Binding Kinase 1) is a Protein Coding gene. Diseases associated with TBK1 include Encephalopathy, Acute, Infection-Induced 8 and Frontotemporal Dementia …
Mechanism of TBK1 activation in cancer cells - PMC
TANK-binding kinase 1 (TBK1) is a serine/threonine kinase with well-established roles as a central player in innate immune signaling. Dysregulation of TBK1 activity has been implicated …
TBK1 TANK binding kinase 1 [ (human)] - National Center for ...
Feb 9, 2025 · TBK1-associated glaucoma exhibits classic features of NTG. Patients present with severe disease at a relatively early age and most (67%) have slow-to-moderate progression of …
Targeting TBK1 to overcome resistance to cancer immunotherapy
Jan 12, 2023 · Using a suite of genetic and pharmacological tools across multiple experimental model systems, we confirm a role for TBK1 as an immune-evasion gene. Targeting TBK1 …
TBK1 and IKKε prevent premature cell death by limiting the
Mar 7, 2025 · TBK1 (TANK binding kinase 1) and IKKε [inhibitor of nuclear factor κ B (NF- K B) kinase subunit ε] are two central kinases in the regulation of several cellular processes and …
Human TBK1 deficiency leads to autoinflammation driven by TNF …
Aug 6, 2021 · Homozygous LoF TBK1 produces systemic autoinflammation, not overt viral disease. Expressed but inactive TBK1 inhibits IFN-I induction more than no TBK1. …
Emerging roles of TBK1 in cancer immunobiology - Cell Press
Mar 21, 2024 · TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation.
TBK1 (TANK-binding kinase 1)-mediated regulation of …
Jun 1, 2021 · TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a broad spectrum of functions in cells. These range from innate immunity, inflammation and …