TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates in blood cell formation, forms …

Mar 1, 1998 · Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. Ono Y et …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy derived from thymic T-cell precursors. Approximately 40-60% of T-ALL cases exhibit aberrant overexpression of the …

Apr 11, 2025 · Polyclonal Antibody for studying TAL1. Validated for WB. Highly specific and rigorously validated in-house, TAL1 Antibody (CST #12831) is ready to ship.

Nov 11, 2012 · Here we reported that PKA mediated phosphorylation regulates TAL1 interaction with the lysine specific demethylase (LSD1) that removes methyl group from methylated Lys 4 …

Feb 2, 2011 · TAL1/SCL is a master regulator of haematopoiesis whose expression promotes opposite outcomes depending on the cell type: differentiation in the erythroid lineage or …

Jun 6, 2009 · We found that TAL1 recruits LSD1 complexes and HDM activity to a TAL1 target promoter. It represses transcription of the target gene by altering the histone H3K4 methylation …

May 1, 2023 · We identified a putative novel oncogenic neo-enhancer downstream of TAL1 in an unresolved monoallelic TAL1+ case. A rare but recurrent somatic heterozygous microinsertion …

TAL1, also known as SCL, is a transcription factor that plays a crucial role in early hematopoiesis. It is expressed in normal erythroid precursors and megakaryocytes, but not in normal T cells.

Jul 1, 2019 · The gene encodes a large (150 kDa) cytosolic protein implicated in regulation of the mitotic spindle checkpoint. It is required for the procentriole assembly and the regulation of the …