Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene. [5][6]

Mar 30, 2025 · TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed: 25412659, 27007846, 33795473). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed: 33795473).

We describe an X-linked genetic syndrome associated with mutations in TAF1 and manifesting with global developmental delay, intellectual disability (ID), characteristic facial dysmorphology, generalized hypotonia, and variable neurologic features, all in male individuals.

The TATA-box binding protein associated factor 1 (TAF1) protein is a key unit of the transcription factor II D complex that serves a vital function during transcription initiation. Variants of TAF1 have been associated with neurodevelopmental ...

The TAF1 gene provides instructions for making part of a protein called transcription factor IID (TFIID). This protein is active in cells and tissues throughout the body, where it attaches (binds) to DNA.

Jul 24, 2019 · The TATA-box binding protein associated factor 1 (TAF1) protein is a key unit of the transcription factor II D complex that serves a vital function during transcription initiation. Variants of TAF1 have been associated with neurodevelopmental disorders, but TAF1's molecular functions remain elusive. …

TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease. TAF1 promotes NSCLC cell epithelial-mesenchymal transition by transcriptionally activating TGFbeta1.

Sep 25, 2024 · TAF1 is dysregulated in X-linked dystonia–parkinsonism and congenital mutations in the gene are causative for neurodevelopmental phenotypes; TAF1 dysfunction is also associated with cardiac anomalies and cancer. However, how …

Chromosomal location: Xq13.1 OMIM: 313650 HGNC: 11535 UniProtKB: P21675 Genatlas: TAF1

Apr 3, 2024 · TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease. TAF1 promotes NSCLC cell epithelial-mesenchymal transition by transcriptionally activating TGFbeta1. Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB.