Trypanosoma brucei is a species of parasitic kinetoplastid belonging to the genus Trypanosoma that is present in sub-Saharan Africa. Unlike other protozoan parasites that normally infect blood and tissue cells, it is exclusively extracellular and inhabits the blood plasma and body fluids. [1] .

Trypanosomiasis is a parasitic infection that spreads through the bites of tsetse flies in equatorial Africa. Early symptoms include swollen bumps around the bite, a fever, and muscle and joint pain. Advanced symptoms cause confusion and trouble walking, and make it difficult to stay awake.

Two subspecies that are morphologically indistinguishable cause distinct disease patterns in humans: T. b. gambiense, causing chronic African trypanosomiasis (“West African sleeping sickness”) and T. b. rhodesiense, causing acute African …

Mar 10, 2025 · Sleeping sickness (i.e., human African trypanosomiasis or HAT) is caused by the parasite Trypanosoma brucei. A parasite is an organism (a living thing) that lives on or inside another organism. Sleeping sickness spreads through the bite of a tsetse fly (Glossina species), found only in rural, sub-Saharan Africa. The disease causes death if left ...

May 2, 2023 · Trypanosoma brucei rhodesiense, found in 13 countries of eastern and southern Africa accounts for 8% of reported cases and causes an acute disease. First signs and symptoms emerge a few weeks or months after infection. The disease develops rapidly with multi-organ invasion, including the brain.

Feb 24, 2024 · Human African trypanosomiasis, also termed “African sleeping sickness,” is an infectious disease transmitted by the tsetse fly and caused by the organisms Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense.

Human African trypanosomiasis (HAT), also known as African sleeping sickness or simply sleeping sickness, is caused by the species Trypanosoma brucei. [3] . Humans are infected by two types, Trypanosoma brucei gambiense (TbG) and Trypanosoma brucei rhodesiense (TbR). [3] . TbG causes over 92% of reported cases. [1] .

Trypanosoma brucei causes African trypanosomiasis in humans and nagana in domestic animals. This vector-borne parasite, transmitted by the tsetse fly, affects rural areas in sub-Saharan Africa.

Trypanosoma brucei is a protozoan that causes human African trypanosomiasis (HAT) or sleeping sickness in sub-Saharan African countries and has a devastating impact on human health.

Trypanosoma brucei, or African trypanosome, is a ubiquitous unicellular flagellated protozoan. It is the causal agent of African sleeping sickness and is transmitted by the tse-tse fly. African trypanosomiasis is a zoonosis and both cattle and wild game can act as reservoirs of human infective trypanosomes.