The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop.

Jul 1, 2003 · Interleukin-4 (IL-4) is crucial for the differentiation of naive T helper (T H) cells into the T H 2 effector cells that promote humoral (antibody) immunity and provide protection against...

IL-4 may directly act on naïve CD4 T cells during T-cell activation to induce Th2 cell differentiation. STAT6 activation by IL-4 is necessary and sufficient during this process 39. The initial source of IL-4 could be basophils, NKT cells, or naïve CD4 T cells themselves.

Nov 15, 2022 · Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 (CART19) has shown remarkable overall response rates in the treatment of hematological malignancies. However, durable response rates remain at approximately 40%.

We recently showed that IL-4, a T-cell-derived cytokine, is a critical participant in higher brain functions such as memory and learning (5). Mice lacking IL-4 demonstrate cognitive impairment in spatial learning tasks, and this can be reversed by transplantation of IL-4 …

Sep 25, 2024 · Here we show that an interleukin-4 fusion protein (Fc–IL-4), a typical type 2 cytokine, directly acts on CD8 + T cells and enriches functional terminally exhausted CD8 + T (CD8 + T TE) cells...

Sep 12, 2024 · Here, Stewart et al discover a role for IL-4 in driving CD8+ CAR-T cell exhaustion and demonstrate the improvement of CAR-T cell effectivity with interruption of IL-4 signalling.

Here, we demonstrate that T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes.

Sep 7, 2021 · Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target cells spanning the innate and adaptive immune systems and is produced by multiple different cellular sources.

Jan 9, 2014 · Interleukin-4 (IL-4), a short four-helix bundle peptide member of the γ-chain receptor cytokine family, is a pleiotropic cytokine produced mainly by Th2 lymphocytes, basophils, and mast cells in response to a receptor-mediated activation (Rozwarski et …