‘Super p53’ mice, carrying p53-tg alleles in addition to the two endogenous alleles, exhibit an enhanced response to DNA damage. Importantly, ‘super p53’ mice are significantly protected from cancer when compared with normal mice.

The super p53 mice carry extra copies of a complete p53 gene, including the p53 promoter and upstream regulatory region . As expected, these mice display augmented p53 activity in response to DNA damage and are tumor-resistant.

Nov 21, 2002 · One of the most intensively studied of cellular molecules, the p53 protein is well known for its role as a tumour suppressor: it helps to protect against cancer by regulating the response of...

Nov 15, 2002 · These “super p53” mice not only showed enhanced activation of the p53-dependent response to DNA damage, but they developed significantly fewer tumors after exposure to chemical carcinogens.

More than half of human cancers contain mutations in the tumor suppressor protein p53, most of which accumulate in the DNA binding domain of the protein. Here we report the identification of a mutant p53, designated p53–46F, in which Ser‐46 is replaced with phenylalanine.

Garcia-Cao and collaborators report the generation of novel transgenic mice, called “super p53.” The super p53 mice express wild-type endogenous p53, and also carry one or two extra copies of a normal p53 gene, inserted as transgenes in the form of …

Jun 7, 2013 · Garcia-Cao et al. (2002) generated “super p53” mice carrying supernumerary fully functional copies of the p53 gene in the form of large genomic transgenes. These super p53 mice were significantly protected from cancer when compared with normal mice and showed no indication of premature ageing.

Jul 7, 2016 · Super p53 mice had significantly reduced survival compared to WT p53 mice (Figure 1B), demonstrating that an extra copy of p53 sensitizes mice to the hematopoietic acute radiation syndrome.

'Super p53' mice, carrying p53‐tg alleles in addition to the two endogenous alleles, exhibit an enhanced response to DNA damage. Importantly, 'super p53' mice are significantly protected from cancer when compared with normal mice.

In line with phenotypes of p53 +/m and P+/+ mice, Garcia-Cao et al. showed that transgenic mice carrying one or two extra copies of wild-type p53 genes (super-p53 or p53 tg mice) were remarkably cancer resistant.