STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or …

The first two STAT proteins were identified in the interferon system. There are seven mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 …

Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. It helps control cell growth and division (proliferation), cell movement (migration), and the self …

Mar 30, 2025 · STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Syndrome 1, Autosomal Dominant, …

STAT3 is a transcription fac-tor, a type of protein that regulates when other genes are turned on. Once activated, STAT3 moves into the nucleus of the cell and binds to specific areas of DNA. …

Dec 3, 2015 · STAT3 is both a transcription activator and an oncogene that is tightly regulated under normal physiological conditions. However, abundant evidence indicates that STAT3 is …

PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile …

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to …

STAT3 functions as a central regulator where multiple signaling pathways are activated by various molecules, including specific cytokines, peptide ligands, growth factors, and oncogenes [5, 6]. …

STAT3 is an 89-kDa (770 amino acids) latent cytoplasmic transcription factor characterized by containing each of the following structural protein domains; N-terminal, coiled-coil, DNA …