Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/ transcription factor) encoded by the SRY gene …

SRY (which stands for sex-determining region Y gene) is found on the Y chromosome. In the cell, it binds to other DNA and in doing so distorts it dramatically out of shape. This alters the …

The SRY gene provides instructions for making a protein called the sex-determining region Y protein. This protein is involved in male-typical sex development, which usually follows a …

In this Chapter I review the structure of SRY and discuss current questions related to possible biochemical mechanisms of testicular differentiation. SRY belongs to a subfamily of related …

Dec 20, 2023 · There are several types of SRY gene variants that can occur, including point mutations, deletions, and rearrangements. These variants can disrupt the normal structure or …

Dec 31, 2013 · The Sex-determining Region Y (Sry in mammals but SRY in humans) is a gene found on Y chromosomes that leads to the development of male phenotypes, such as testes. …

Disorders of sex development can be classified into several categories including chromosomal, gonadal, and anatomic abnormalities. Genetic tools such as microarray analyses and next …

Mar 1, 2025 · Here, we present the functional analysis of five SRY coding variants identified in patients with 46, XY DSD. Four variants (p.Asp58Glu, p.Arg75Lys, p.Met85Thr, and …

Mar 30, 2025 · SRY (Sex Determining Region Y) is a Protein Coding gene. Diseases associated with SRY include 46,Xx Sex Reversal 1 and 46,Xy Sex Reversal 1. Among its related …

Jun 12, 2024 · The optimal management of 46, XY complete gonadal dysgenesis requires a multidisciplinary collaboration. Patients with this condition are at increased risk of gonadal …