Jul 4, 2024 · Superparamagnetic iron oxides (SPIOs) are a class of MR contrast agents composed of nanoparticles of iron oxide crystals coated in carbohydrates. They are used to image vasculature and the liver via shortening T1 and T2/T2* relaxation times.

In this article, a brief review of superparamagnetic iron oxide (SPIO) based MRI contrast agents and their current clinical applications are presented. A conglomerate of numerous nano-sized iron oxide crystals coated with dextran or carboxydextran forms SPIO contrast agents (1).

Compared to T1 agents, superparamagnetic iron oxide NPs (SPIONs) based T2 agents appear to be the preferred MRI contrast agents for monitoring stem cells due to their high sensitivity and excellent biocompatibility 40.

Feb 25, 2015 · SPIONs as contrast agents are therefore useful for the in vivo MRI detection of macrophage infiltration, and there is substantial research and clinical interest in the use of SPION-based contrast agents for MRI of infection and inflammation.

Aug 3, 2011 · Superparamagnetic iron oxide (SPIO) MR contrast agents are composed of nano-sized iron oxide crystals coated with dextran or carboxydextran. Two SPIO agents are clinically approved, namely: ferumoxides (Feridex in the USA, Endorem in Europe) with a particle size of 120 to 180 nm, and ferucarbotran ( …

Feb 9, 2017 · SPIOs have been tested on MR angiography, sentinel lymph node detection, lymph node metastasis evaluation; inflammation evaluation; blood volume measurement; as well as liver imaging. Two experimental SPIOs with unique potentials are also discussed in this review.

Dec 1, 2011 · Superparamagnetic iron oxide (SPIO) MR contrast agents are composed of nano-sized iron oxide crystals coated with dextran or carboxydextran. Two SPIO agents are clinically approved,...

Jun 9, 2021 · Superparamagnetic iron oxide (SPIO) is a liver-specific contrast agent that can selectively visualize liver tumors, even if plain MRI does not depict them. The purpose of this study was to present a proof of concept of SPIO-enhanced MRI …

Superparamagnetic iron oxide nanoparticles (SPION) based magnetic resonance imaging (MRI) is a powerful non-invasive tool in biomedical imaging, clinical diagnosis and therapy.

There are two types of contrast agent based on superparamagnetic iron oxides: SPIO (Superparamagnetic Iron Oxide) for liver tropism and USPIO (Ultrasmall Superparamagnetic Iron Oxide) for ganglion tropism.