Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene. [5] [6] [7] The protein encoded by this gene contains a SH2 domain and a CIS homolog domain.

Mar 30, 2025 · SOCS6 (Suppressor Of Cytokine Signaling 6) is a Protein Coding gene. Diseases associated with SOCS6 include Borderline Glaucoma and Somatization Disorder . Among its …

SOCS6 negatively regulates Flt3 activation, the downstream Erk signaling pathway, and cell proliferation. Reduced copy number and mRNA expression of SOCS6 are associated with …

Decreased SOCS6 expression is involved in diverse tumorigenic processes, such as abnormal cell proliferation, evasion of apoptosis, cancer migration, and cancer stem cell maintenance. …

SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by …

Sep 7, 2012 · SOCS6 promotes intrinsic apoptosis, with increased Bax conformational change, mitochondrial targeting, and oligomerization. Most importantly, SOCS6 is targeted to …

Dec 10, 2024 · SOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting Angiogenesis in Human Prostate Cancer. Yuan D, et al. Curr Cancer Drug Targets, 2018. …

SOCS6 promotes intrinsic apoptosis, with increased Bax conformational change, mitochondrial targeting, and oligomerization. Most importantly, SOCS6 is targeted to mitochondria and …

Aug 30, 2014 · SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces …

Apr 1, 2022 · Decreased SOCS6 expression is involved in diverse tumorigenic processes, such as abnormal cell proliferation, evasion of apoptosis, cancer migration, and cancer stem cell …