SOAT1 is a polytopic integral membrane protein belonging to the membrane-bound O-acyltransferase (MBOAT) superfamily. The structure of SOAT1 has not yet been solved but …

Mar 30, 2025 · SOAT1 (Sterol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with SOAT1 include Niemann-Pick Disease, Type C1 and Chronic Leukemia. …

May 9, 2024 · Here we demonstrated that SOAT1 positively related to poor prognosis of HCC, EMT markers and promoted cell migration and invasion in vitro, which was mediated by the …

Sep 7, 2020 · We identified sterol O-acyltransferase 1 (SOAT1) as a key player in sustaining the mevalonate pathway by converting cholesterol to inert cholesterol esters, thereby preventing …

SOAT1 suppression might be a new therapeutic option in regard to targeting GBM growth and invasiveness. The higher expression in cells related to neuroinflammation compared to the …

High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. …

Jun 22, 2018 · Sterol O-acyltransferase 1 (SOAT1) is a key enzyme for cholesteryl ester biosynthesis. The objective of the present study is to investigate the role and underlying …

In this review, we mainly discuss the cholesterol metabolism centered on SOAT1 and mechanisms that regulate SOAT1 expression in cancers. Finally, the latest developments that …

May 18, 2020 · Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate …

May 18, 2020 · Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase …